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Instruct patients on the proper use of IMITREX STATdose Pen and direct them to use injection sites with an adequate skin and subcutaneous thickness to accommodate the length of the needle Imitrex is a medicine that is used in the treatment of migraines. Sumatriptan works in the brain to relieve the pain from migraine headaches. Place the autoinjector at a 90-degree angle at the skin injection site with the yellow needle guard gently pressed against the skin. Many people find that their headaches go away completely after they use sumatriptan commonly occur after treatment with IMITREX injection and are usually non-cardiac in origin. You should inject it under the skin of your belly, upper arms, or thighs. Avoid driving and doing other tasks or actions that call for you to be alert until you see how Imitrex (sumatriptan injection) affects you Sumatriptan is injected under the skin. 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